WebIn this study, phytochemical analysis of Nothapodytes tomentosa resulted in the isolation and identification of CPT (13) and 16 analogues (1-12, 14-17), including a new (1) and five known (9, 10, 12, 15 and 17) CPT analogues with an open E-ring. In view of the potential anticancer activity of CPT analogues with an open E-ring, the fragmentation ... WebNothapodytes nimmoniana (Icacinaceae), a small tree distributed in the Indian subcontinent. Because of the enormous demand for the chemical worldwide, there has been an indiscriminate extraction of the trees from many parts of India, especially from the Western Ghats, a mega-diversity forest range along the western coast of India.
Nothapodytes nimmoniana - Wikipedia
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Nothapodytes nimmoniana (J.Graham) Mabb. - World …
WebNothapodytes nimmoniana (Graham) Mabb. belonging to the family, Icacinaceae is a medicinally valuable tree. It is a native of Indomalaysia and Indochina. Barks of N. nim- WebNothapodytes nimmoniana (J. Graham) Mabberly is an endangered medicinal woody plant native to the South Asian continent (Isah, 2024). The plant synthesizes monoterpene indole alkaloid Camptothecin (CPT) which is well-studied for its antitumor properties. The CPT is effective against breast, lung, and uterine cervical cancer (Potmesil, 1986 ... WebDec 1, 2024 · For the first time, CPT was obtained from the extracts of a Chinese medicinal tree, Camptotheca acuminata Decne. from the family Cornaceae. Subsequently, CPT was also isolated from the bark of Nothapodytes foetida (Wight) Sleumer (Icacinaceae). However, the availability of enough natural sources for obtaining CPT is a major constraint. starlite investment group