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Marchiafava Bignami Disease: A Rare Neurological Complication …
WebJan 27, 2024 · Marchiafava-Bignami disease (MBD) is a very rare disorder characterized by demyelination and necrosis of the corpus callosum. The adjacent subcortical white matter may also be involved. This activity … MBD symptoms can vary by person. Subtle signs might include: 1. Decreased consciousness 2. Psychotic symptoms 3. Depression 4. Apathy 5. Aggressiveness 6. Difficulty speaking The disease is often divided into three categories: chronic, subacute, or acute. The chronic form of … See more MBD occurs when nerves of the corpus callosum—the area between the brain's hemispheres—become demyelinated, or eroded. The erosion damages the nerves and eventually leads … See more Diagnosing MBD requires magnetic resonance imaging (MRI). An MRI is a noninvasive diagnostic test that uses radiofrequency and … See more The outlook for patients with MBD is highly variable. Generally speaking, the outlook is more positive with an early diagnosis and prompt treatment. However, this can also vary from person to person. Some patients survive for … See more Because MBD is closely associated with decreased B vitamins, intravenous (IV) thiamine may be given to treat patients. Recovery also includes neurological and psychological … See more the san mateo times
Acute Marchiafava-Bignami disease: Clinical and serial MRI …
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